DNA polymerase catalytic subunit

BE0000343ProteinHHV-5UL54

Replicates viral genomic DNA in the late phase of lytic infection, producing long concatemeric DNA. It is acted on by 5 drugs in DrugBank.

Gene name
UL54
UniProtKB entry
P08546Swiss-Prot
Cellular location
Host nucleus
Residues / weight
1,242 residues · 137,101 Da
Also known as
2.7.7.7 · HFLF2

Resolves to

Protein
UniProtP08546UniProt nameDPOL_HCMVA
Gene
GenBank1780831
Structure
PDB1YYP
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase catalytic subunit, how selective are they, and which programs against it are still in active trials?

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