Foscarnet is an antiviral used to treat CMV, HIV, and HSV infections. An antiviral agent used in the treatment of cytomegalovirus retinitis.
- Mechanism
- Curator reviewed
Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.
- Primary indication
- For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.Curator reviewed · 4 structured indications
- Formula / weight
- CH3O5P · 126.0053 g/mol (avg)
- First approval
- Canada, 2020 · United States, 2006
- Also known as
- Carboxyphosphonic acid · Foscarmet · Phosphonoformate · Phosphonoformic acid · Phosphonomethanoic acid
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
ZJAOAACCNHFJAH-UHFFFAOYSA-NSMILESOC(=O)P(O)(O)=OTransporters
What you can answer from here — as of September 12, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
2TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Foscarnet, and which of those have an active Phase 3 trial?
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