Glycine amidinotransferase, mitochondrial

BE0000347ProteinHumansGATM

Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives (PubMed:16820567, PubMed:27233232, PubMed:36543883,... It is acted on by 6 drugs in DrugBank.

Gene name
GATM
UniProtKB entry
P50440Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
423 residues · 48,455 Da
Also known as
2.1.4.1 · AGAT · L-arginine:glycine amidinotransferase · Transamidinase

Resolves to

Protein
UniProtP50440UniProt nameGATM_HUMAN
Gene
HGNCHGNC:4175NCBI Gene2628GenBank545385GeneCardsGATM
Pharmacology
KEGGhsa:2628
Structure
PDB1JDWPDB1JDXPDB2JDW
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glycine amidinotransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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