Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

BE0000355ProteinHumansSUCLG2

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:40108300). It is acted on by 2 drugs in DrugBank.

Gene name
SUCLG2
UniProtKB entry
Q96I99Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
432 residues · 46,510 Da
Also known as
6.2.1.4 · G-SCS · GTP-specific succinyl-CoA synthetase subunit beta · GTPSCS · Itaconyl--CoA ligase [GDP-forming] subunit beta

Resolves to

Protein
UniProtQ96I99UniProt nameSUCB2_HUMAN
Gene
HGNCHGNC:11450NCBI Gene8801GenBank133777003GeneCardsSUCLG2
Pharmacology
KEGGhsa:8801
Structure
PDB6WCVPDB7MSRPDB7MSS
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial, how selective are they, and which programs against it are still in active trials?

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