All-trans-retinol dehydrogenase [NAD(+)] ADH4

BE0000360ProteinHumansADH4

Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). It is acted on by 4 drugs in DrugBank.

Gene name
ADH4
UniProtKB entry
P08319Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
380 residues · 40,221 Da
Also known as
1.1.1.105 · ADH2 · Alcohol dehydrogenase 2 · Alcohol dehydrogenase 4 · Alcohol dehydrogenase class II pi chain

Resolves to

Protein
UniProtP08319UniProt nameADH4_HUMAN
Gene
HGNCHGNC:252NCBI Gene127GenBank178121GeneCardsADH4
Pharmacology
KEGGhsa:127
Structure
PDB3COS
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on All-trans-retinol dehydrogenase [NAD(+)] ADH4, how selective are they, and which programs against it are still in active trials?

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