Tyrosine--tRNA ligase, mitochondrial

BE0000363ProteinHumansYARS2

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). It is acted on by 1 drug in DrugBank.

Gene name
YARS2
UniProtKB entry
Q9Y2Z4Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
477 residues · 53,199 Da
Also known as
6.1.1.1 · Tyrosyl-tRNA synthetase · TyrRS

Resolves to

Protein
UniProtQ9Y2Z4UniProt nameSYYM_HUMAN
Gene
HGNCHGNC:24249NCBI Gene51067GenBank4680649GeneCardsYARS2
Pharmacology
KEGGhsa:51067
Structure
PDB2PIDPDB3ZXI
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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