Glutamate decarboxylase 1

BE0000378ProteinHumansGAD1

Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor. It is acted on by 2 drugs in DrugBank.

Gene name
GAD1
UniProtKB entry
Q99259Swiss-Prot
Residues / weight
594 residues · 66,896 Da
Also known as
4.1.1.15 · 67 kDa glutamic acid decarboxylase · GAD · GAD-67 · GAD67

Resolves to

Protein
UniProtQ99259UniProt nameDCE1_HUMAN
Gene
HGNCHGNC:4092NCBI Gene2571GenBank182936GeneCardsGAD1
Pharmacology
KEGGhsa:2571
Structure
PDB2OKJPDB3VP6
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamate decarboxylase 1, how selective are they, and which programs against it are still in active trials?

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