Aspartate aminotransferase, mitochondrial

BE0000383ProteinHumansGOT2

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). It is acted on by 7 drugs in DrugBank.

Gene name
GOT2
UniProtKB entry
P00505Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
430 residues · 47,517 Da
Also known as
2.6.1.1 · 2.6.1.7 · FABP-1 · FABPpm · Fatty acid-binding protein

Resolves to

Protein
UniProtP00505UniProt nameAATM_HUMAN
Gene
HGNCHGNC:4433NCBI Gene2806GenBank179104GeneCardsGOT2
Pharmacology
KEGGhsa:2806
Structure
PDB5AX8PDB8SKRPDB9YB6
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aspartate aminotransferase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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