Serine racemase

BE0000388ProteinHumansSRR

Pyridoxal-5'-phosphate (PLP)-dependent enzyme that catalyzes the synthesis of D-serine from L-serine (PubMed:20106978, PubMed:23391306, PubMed:29277459). It is acted on by 3 drugs in DrugBank.

Gene name
SRR
UniProtKB entry
Q9GZT4Swiss-Prot
Residues / weight
340 residues · 36,566 Da
Also known as
5.1.1.18 · D-serine ammonia-lyase · D-serine dehydratase · L-serine ammonia-lyase · L-serine dehydratase

Resolves to

Protein
UniProtQ9GZT4UniProt nameSRR_HUMAN
Gene
HGNCHGNC:14398NCBI Gene63826GenBank11034785GeneCardsSRR
Pharmacology
KEGGhsa:63826
Structure
PDB3L6BPDB3L6RPDB5X2L
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine racemase, how selective are they, and which programs against it are still in active trials?

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