Kynureninase

BE0000392ProteinHumansKYNU

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. It is acted on by 4 drugs in DrugBank.

Gene name
KYNU
UniProtKB entry
Q16719Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
465 residues · 52,351 Da
Also known as
3.7.1.3 · L-kynurenine hydrolase

Resolves to

Protein
UniProtQ16719UniProt nameKYNU_HUMAN
Gene
HGNCHGNC:6469NCBI Gene8942GenBank1323715GeneCardsKYNU
Pharmacology
KEGGhsa:8942
Structure
PDB2HZPPDB3E9KPDB7S3V
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kynureninase, how selective are they, and which programs against it are still in active trials?

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