Isovaleryl-CoA dehydrogenase, mitochondrial

BE0000397ProteinHumansIVD

A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA (PubMed:7640268). It is acted on by 2 drugs in DrugBank.

Gene name
IVD
UniProtKB entry
P26440Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
426 residues · 46,650 Da
Also known as
1.3.8.4 · Butyryl-CoA dehydrogenase · IVD

Resolves to

Protein
UniProtP26440UniProt nameIVD_HUMAN
Gene
HGNCHGNC:6186NCBI Gene3712GenBank306897GeneCardsIVD
Pharmacology
KEGGhsa:3712
Structure
PDB1IVHPDB8SGRPDB9JQ3
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isovaleryl-CoA dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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