L-lactate dehydrogenase A chain

BE0000425ProteinHumansLDHA

Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). It is acted on by 9 drugs in DrugBank.

Gene name
LDHA
UniProtKB entry
P00338Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
332 residues · 36,688 Da
Also known as
1.1.1.27 · Cell proliferation-inducing gene 19 protein · LDH muscle subunit · LDH-A · LDH-M

Resolves to

Protein
UniProtP00338UniProt nameLDHA_HUMAN
Gene
HGNCHGNC:6535NCBI Gene3939GenBank34313GeneCardsLDHA
Pharmacology
KEGGhsa:3939
Structure
PDB1I10PDB4AJPPDB4JNK
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on L-lactate dehydrogenase A chain, how selective are they, and which programs against it are still in active trials?

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