Serine palmitoyltransferase 1

BE0000441ProteinHumansSPTLC1

Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. It is acted on by 2 drugs in DrugBank.

Gene name
SPTLC1
UniProtKB entry
O15269Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
473 residues · 52,743 Da
Also known as
2.3.1.50 · LCB 1 · LCB1 · Long chain base biosynthesis protein 1 · Serine-palmitoyl-CoA transferase 1

Resolves to

Protein
UniProtO15269UniProt nameSPTC1_HUMAN
Gene
HGNCHGNC:11277NCBI Gene10558GenBank2564247GeneCardsSPTLC1
Pharmacology
KEGGhsa:10558
Structure
PDB6M4NPDB6M4OPDB7CQI
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine palmitoyltransferase 1, how selective are they, and which programs against it are still in active trials?

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