Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

BE0000445ProteinHumansMCCC1

Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. It is acted on by 1 drug in DrugBank.

Gene name
MCCC1
UniProtKB entry
Q96RQ3Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
725 residues · 80,472 Da
Also known as
3-methylcrotonyl-CoA carboxylase 1 · 3-methylcrotonyl-CoA carboxylase biotin-containing subunit · 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha · 6.4.1.4 · MCCA

Resolves to

Protein
UniProtQ96RQ3UniProt nameMCCA_HUMAN
Gene
HGNCHGNC:6936NCBI Gene56922GenBank12382296GeneCardsMCCC1
Pharmacology
KEGGhsa:56922
Structure
PDB2EJMPDB8J4ZPDB8J78
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial, how selective are they, and which programs against it are still in active trials?

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