Leucine carboxyl methyltransferase 1

BE0000450ProteinHumansLCMT1

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. It is acted on by 1 drug in DrugBank.

Gene name
LCMT1
UniProtKB entry
Q9UIC8Swiss-Prot
Residues / weight
334 residues · 38,379 Da
Also known as
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 · 2.1.1.233 · LCMT · Protein-leucine O-methyltransferase

Resolves to

Protein
UniProtQ9UIC8UniProt nameLCMT1_HUMAN
Gene
HGNCHGNC:17557NCBI Gene51451GenBank6580758GeneCardsLCMT1
Pharmacology
KEGGhsa:51451
Structure
PDB3IEIPDB3O7WPDB3P71
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
11+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Leucine carboxyl methyltransferase 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In