Activin receptor type-1-like

BE0000459ProteinHumansACVRL1

Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. It is acted on by 3 drugs in DrugBank.

Gene name
ACVRL1
UniProtKB entry
P37023Swiss-Prot
Cellular location
Cell membrane
Residues / weight
503 residues · 56,124 Da
Also known as
2.7.11.30 · Activin receptor-like kinase 1 · ACVRLK1 · ALK-1 · ALK1

Resolves to

Protein
UniProtP37023UniProt nameACVL1_HUMAN
Gene
HGNCHGNC:175NCBI Gene94GenBank402197GeneCardsACVRL1
Pharmacology
IUPHAR/GtoPdb1784KEGGhsa:94
Structure
PDB2LCRPDB3MY0PDB4FAO
Drugs

What you can answer from here — as of October 08, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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42GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Activin receptor type-1-like, and which indications are they being tested in?

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