DNA-directed RNA polymerase subunit alpha

BE0000461ProteinEscherichia coli (strain K12)rpoA

DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is acted on by 2 drugs in DrugBank.

Gene name
rpoA
UniProtKB entry
P0A7Z4Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
329 residues · 36,511 Da
Also known as
2.7.7.6 · pez · phs · RNA polymerase subunit alpha · RNAP subunit alpha

Resolves to

Protein
UniProtP0A7Z4UniProt nameRPOA_ECOLI
Gene
NCBI Gene947794GenBank147715
Pharmacology
KEGGecj:JW3257
Structure
PDB1BDFPDB1COOPDB1LB2
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA-directed RNA polymerase subunit alpha, how selective are they, and which programs against it are still in active trials?

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