Aldehyde dehydrogenase family 1 member B1, mitochondrial

BE0000479ProteinHumansALDH1B1

Broad specificity, mitochondrial aldehyde dehydrogenase that could play a role in the detoxification of alcohol-derived acetaldehyde and other aldehydes (PubMed:20616185, PubMed:25413692, PubMed:35788181). It is acted on by 2 drugs in DrugBank.

Gene name
ALDH1B1
UniProtKB entry
P30837Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
517 residues · 57,249 Da
Also known as
1.2.1.28 · 1.2.1.3 · 1.2.1.36 · Aldehyde dehydrogenase 5 · Aldehyde dehydrogenase X

Resolves to

Protein
UniProtP30837UniProt nameAL1B1_HUMAN
Gene
HGNCHGNC:407NCBI Gene219GenBank1263008GeneCardsALDH1B1
Pharmacology
KEGGhsa:219
Structure
PDB7MJCPDB7MJDPDB7RAD
Drugs

What you can answer from here — as of June 19, 2026

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Aldehyde dehydrogenase family 1 member B1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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