NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

BE0000485ProteinHumansNDUFV1

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:28844695). It is acted on by 2 drugs in DrugBank.

Gene name
NDUFV1
UniProtKB entry
P49821Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
464 residues · 50,817 Da
Also known as
7.1.1.2 · CI-51kD · Complex I-51kD · NADH dehydrogenase flavoprotein 1 · NADH-ubiquinone oxidoreductase 51 kDa subunit

Resolves to

Protein
UniProtP49821UniProt nameNDUV1_HUMAN
Gene
HGNCHGNC:7716NCBI Gene4723GenBank3184148GeneCardsNDUFV1
Pharmacology
KEGGhsa:4723
Structure
PDB5XTBPDB5XTDPDB5XTH
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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