Rotenone

DB11457ExperimentalVet approvedSmall molecule

Rotenone is an isoflavone compound that naturally occurs in the jicama vine plant as well as many Fabaceae plants. It has broad spectrum insecticide and pesticide activity and is also...

Mechanism: Pharmacologically active on NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial and NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Curator reviewed
Formula / weight: C₂₃H₂₂O₆ · 394.4172 g/mol (avg)
Also known as: Dactinol · Tubatoxin
Code names: NSC-26258

Resolves to

Compound

UNII03L9OT429TCAS83-79-4ChEMBLCHEMBL429023ChEBI28201PubChem6758KEGGC07593

Clinical / RWD

RxNorm1366666

Structure

InChIKeyJUVIOZPCNVVQFO-HBGVWJBISA-NSMILES[H][C@@]12COC3=C(C=C(OC)C(OC)=C3)[C@]1([H])C(=O)C1=CC=C3O[C@H](CC3=C1O2)C(C)=C

Targets

P49821NDUFV1P28331NDUFS1

What you can answer from here — as of July 10, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

21+ReferencesStructured and connected to the statements they support

Which drugs share a target with Rotenone, and which of those have an active Phase 3 trial?

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