Isoleucine--tRNA ligase, cytoplasmic

BE0000491ProteinHumansIARS1

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor... It is acted on by 1 drug in DrugBank.

Gene name
IARS1
UniProtKB entry
P41252Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,262 residues · 144,497 Da
Also known as
6.1.1.5 · IARS · IleRS · IRS · Isoleucyl-tRNA synthetase

Resolves to

Protein
UniProtP41252UniProt nameSYIC_HUMAN
Gene
HGNCHGNC:5330NCBI Gene3376GenBank551622GeneCardsIARS1
Pharmacology
KEGGhsa:3376
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isoleucine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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