Propionyl-CoA carboxylase alpha chain, mitochondrial

BE0000492ProteinHumansPCCA

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other... It is acted on by 2 drugs in DrugBank.

Gene name
PCCA
UniProtKB entry
P05165Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
728 residues · 80,058 Da
Also known as
6.4.1.3 · PCCase subunit alpha · Propanoyl-CoA:carbon dioxide ligase subunit alpha

Resolves to

Protein
UniProtP05165UniProt namePCCA_HUMAN
Gene
HGNCHGNC:8653NCBI Gene5095GenBank296366GeneCardsPCCA
Pharmacology
KEGGhsa:5095
Structure
PDB2CQYPDB2JKUPDB7YBU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Propionyl-CoA carboxylase alpha chain, mitochondrial, how selective are they, and which programs against it are still in active trials?

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