Carnitine O-acetyltransferase

BE0000496ProteinHumansCRAT

Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. It is acted on by 6 drugs in DrugBank.

Gene name
CRAT
UniProtKB entry
P43155Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
626 residues · 70,857 Da
Also known as
2.3.1.137 · 2.3.1.7 · Carnitine acetylase · Carnitine acetyltransferase · CAT

Resolves to

Protein
UniProtP43155UniProt nameCACP_HUMAN
Gene
HGNCHGNC:2342NCBI Gene1384GenBank927415GeneCardsCRAT
Structure
PDB1NM8PDB1S5O
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
28+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Carnitine O-acetyltransferase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In