DNA polymerase I

BE0000498ProteinEscherichia coli (strain K12)polA

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. It is acted on by 2 drugs in DrugBank.

Gene name
polA
UniProtKB entry
P00582Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
928 residues · 103,117 Da
Also known as
2.7.7.7 · POL I · resA

Resolves to

Protein
UniProtP00582UniProt nameDPO1_ECOLI
Gene
NCBI Gene948356GenBank42461
Pharmacology
KEGGecj:JW3835
Structure
PDB1D8YPDB1D9DPDB1D9F
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA polymerase I, how selective are they, and which programs against it are still in active trials?

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