Thyroid peroxidase

BE0000507ProteinHumansTPO

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). It is acted on by 10 drugs in DrugBank.

Gene name
TPO
UniProtKB entry
P07202Swiss-Prot
Cellular location
Membrane
Residues / weight
933 residues · 102,962 Da
Also known as
1.11.1.8 · TPO

Resolves to

Protein
UniProtP07202UniProt namePERT_HUMAN
Gene
HGNCHGNC:12015NCBI Gene7173GenBank339867GeneCardsTPO
Pharmacology
IUPHAR/GtoPdb2526KEGGhsa:7173
Drugs

What you can answer from here — as of September 07, 2019

10DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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66+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thyroid peroxidase, how selective are they, and which programs against it are still in active trials?

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