Argininosuccinate lyase

BE0000520ProteinHumansASL

Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in... It is acted on by 3 drugs in DrugBank.

Gene name
ASL
UniProtKB entry
P04424Swiss-Prot
Residues / weight
464 residues · 51,658 Da
Also known as
4.3.2.1 · Arginosuccinase · ASAL

Resolves to

Protein
UniProtP04424UniProt nameARLY_HUMAN
Gene
HGNCHGNC:746NCBI Gene435GenBank28878GeneCardsASL
Pharmacology
KEGGhsa:435
Structure
PDB1AOSPDB1K62
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Argininosuccinate lyase, how selective are they, and which programs against it are still in active trials?

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