Identification
- Generic Name
- 2-(N-morpholino)ethanesulfonic acid
- DrugBank Accession Number
- DB03814
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for 2-(N-morpholino)ethanesulfonic acid (DB03814)
- Weight
- Average: 195.237
Monoisotopic: 195.056528599 - Chemical Formula
- C6H13NO4S
- Synonyms
- 2-(4-morpholinyl)ethanesulfonic acid
- 2-(morpholin-4-yl)ethanesulfonic acid
- 2-(N-morpholino)ethanesulfonic acid
- 2-morpholinoethanesulphonic acid
- 4-morpholineethanesulfonic acid
- 4-morpholinethanesulfonic acid
- MES
- External IDs
- NSC-157116
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UAcetylcholinesterase Not Available Humans UGlutamine--fructose-6-phosphate aminotransferase [isomerizing] Not Available Escherichia coli (strain K12) UDihydrofolate reductase Not Available Yeast UCopper-containing nitrite reductase Not Available Achromobacter cycloclastes UChymase Not Available Humans UGlutathione S-transferase P Not Available Humans UCorticosteroid 11-beta-dehydrogenase isozyme 1 Not Available Humans UHydroxylamine reductase Not Available Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949) UDiaminopimelate decarboxylase Not Available Escherichia coli (strain K12) UAlpha-xylosidase Not Available Escherichia coli (strain K12) ULimonene-1,2-epoxide hydrolase Not Available Rhodococcus erythropolis UMannan endo-1,4-beta-mannosidase Not Available Cellvibrio japonicus (strain Ueda107) UBeta-1,4-galactosyltransferase 1 Not Available Humans UTyrosine-protein kinase transforming protein Abl Not Available Abelson murine leukemia virus UBifunctional protein GlmU Not Available Escherichia coli (strain K12) UThiol:disulfide interchange protein DsbC Not Available Escherichia coli (strain K12) UGlyceraldehyde-3-phosphate dehydrogenase A Not Available Escherichia coli (strain K12) U(S)-mandelate dehydrogenase Not Available Pseudomonas putida UDissimilatory copper-containing nitrite reductase Not Available Alcaligenes xylosoxydans xylosoxydans U33 kDa chaperonin Not Available Escherichia coli (strain K12) UFree methionine-R-sulfoxide reductase Not Available Escherichia coli (strain K12) UOrnithine cyclodeaminase Not Available Pseudomonas putida (strain KT2440) UDihydropteridine reductase Not Available Humans UArgininosuccinate lyase Not Available Humans UO-acetyl-ADP-ribose deacetylase Not Available Escherichia coli (strain K12) UADP-ribosylation factor-like protein 3 Not Available Humans UBeta-lactamase Not Available Proteus vulgaris U3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC Not Available Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) ULethal(3)malignant brain tumor-like protein 1 Not Available Humans UCholinesterase Not Available Humans URibonuclease Z Not Available Bacillus subtilis (strain 168) UPeroxiredoxin-6 Not Available Humans UHypothetical gliding protein Not Available Thermus thermophilus UProlyl endopeptidase Pep Not Available Myxococcus xanthus UPulmonary surfactant-associated protein A1 Not Available Humans UManganese catalase Not Available Lactobacillus plantarum UChorismate mutase AroH Not Available Thermus thermophilus UPutative cytochrome P450 Not Available Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) UInterferon-inducible GTPase 5 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as morpholines. These are organic compounds containing a morpholine moiety, which consists of a six-member aliphatic saturated ring with the formula C4H9NO, where the oxygen and nitrogen atoms lie at positions 1 and 4, respectively.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Oxazinanes
- Sub Class
- Morpholines
- Direct Parent
- Morpholines
- Alternative Parents
- Sulfonyls / Organosulfonic acids / Alkanesulfonic acids / Trialkylamines / Oxacyclic compounds / Dialkyl ethers / Azacyclic compounds / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
- Substituents
- Aliphatic heteromonocyclic compound / Alkanesulfonic acid / Amine / Azacycle / Dialkyl ether / Ether / Hydrocarbon derivative / Morpholine / Organic nitrogen compound / Organic oxide
- Molecular Framework
- Aliphatic heteromonocyclic compounds
- External Descriptors
- organosulfonic acid, MES (CHEBI:39005)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2GNK67Q0C4
- CAS number
- 4432-31-9
- InChI Key
- SXGZJKUKBWWHRA-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H13NO4S/c8-12(9,10)6-3-7-1-4-11-5-2-7/h1-6H2,(H,8,9,10)
- IUPAC Name
- 4-(2-sulfonatoethyl)morpholin-4-ium
- SMILES
- OS(=O)(=O)CCN1CCOCC1
References
- General References
- Not Available
- External Links
- PubChem Compound
- 4478249
- PubChem Substance
- 46507795
- ChemSpider
- 70541
- ChEBI
- 39005
- ChEMBL
- CHEMBL1234276
- ZINC
- ZINC000001583444
- PDBe Ligand
- MES
- Wikipedia
- MES_(buffer)
- PDB Entries
- 10gs / 11gs / 12gs / 13gs / 14gs / 16gs / 17gs / 18gs / 19gs / 1a7t … show 1869 more
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 61.1 mg/mL ALOGPS logP -1.8 ALOGPS logP -2.5 Chemaxon logS -0.5 ALOGPS pKa (Strongest Acidic) -1.5 Chemaxon pKa (Strongest Basic) 6.51 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 70.87 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 53.64 m3·mol-1 Chemaxon Polarizability 18.67 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.5 Blood Brain Barrier + 0.9 Caco-2 permeable - 0.6087 P-glycoprotein substrate Non-substrate 0.6448 P-glycoprotein inhibitor I Non-inhibitor 0.6976 P-glycoprotein inhibitor II Non-inhibitor 0.9811 Renal organic cation transporter Non-inhibitor 0.7887 CYP450 2C9 substrate Non-substrate 0.8858 CYP450 2D6 substrate Non-substrate 0.8017 CYP450 3A4 substrate Non-substrate 0.6155 CYP450 1A2 substrate Non-inhibitor 0.8233 CYP450 2C9 inhibitor Non-inhibitor 0.8427 CYP450 2D6 inhibitor Non-inhibitor 0.8844 CYP450 2C19 inhibitor Non-inhibitor 0.8079 CYP450 3A4 inhibitor Non-inhibitor 0.9623 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9671 Ames test AMES toxic 0.5181 Carcinogenicity Non-carcinogens 0.6105 Biodegradation Ready biodegradable 0.9587 Rat acute toxicity 2.3838 LD50, mol/kg Not applicable hERG inhibition (predictor I) Strong inhibitor 0.9425 hERG inhibition (predictor II) Non-inhibitor 0.7564
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Serine hydrolase activity
- Specific Function
- Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
- Gene Name
- ACHE
- Uniprot ID
- P22303
- Uniprot Name
- Acetylcholinesterase
- Molecular Weight
- 67795.525 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Glutamine-fructose-6-phosphate transaminase (isomerizing) activity
- Specific Function
- Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
- Gene Name
- glmS
- Uniprot ID
- P17169
- Uniprot Name
- Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
- Molecular Weight
- 66893.7 Da
References
- Kind
- Protein
- Organism
- Yeast
- Pharmacological action
- Unknown
- General Function
- Nadp binding
- Specific Function
- Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
- Gene Name
- DFR1
- Uniprot ID
- P22906
- Uniprot Name
- Dihydrofolate reductase
- Molecular Weight
- 22138.295 Da
References
- Kind
- Protein
- Organism
- Achromobacter cycloclastes
- Pharmacological action
- Unknown
- General Function
- Nitrite reductase (no-forming) activity
- Specific Function
- Not Available
- Gene Name
- nirK
- Uniprot ID
- P25006
- Uniprot Name
- Copper-containing nitrite reductase
- Molecular Weight
- 40771.115 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Serine-type peptidase activity
- Specific Function
- Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
- Gene Name
- CMA1
- Uniprot ID
- P23946
- Uniprot Name
- Chymase
- Molecular Weight
- 27324.56 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- S-nitrosoglutathione binding
- Specific Function
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
- Gene Name
- GSTP1
- Uniprot ID
- P09211
- Uniprot Name
- Glutathione S-transferase P
- Molecular Weight
- 23355.625 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- 11-beta-hydroxysteroid dehydrogenase [nad(p)] activity
- Specific Function
- Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the rea...
- Gene Name
- HSD11B1
- Uniprot ID
- P28845
- Uniprot Name
- Corticosteroid 11-beta-dehydrogenase isozyme 1
- Molecular Weight
- 32400.665 Da
References
- Kind
- Protein
- Organism
- Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
- Gene Name
- hcp
- Uniprot ID
- Q01770
- Uniprot Name
- Hydroxylamine reductase
- Molecular Weight
- 58658.78 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. Is not active against the DD- or LL-isomers of diaminopimelate.
- Gene Name
- lysA
- Uniprot ID
- P00861
- Uniprot Name
- Diaminopimelate decarboxylase
- Molecular Weight
- 46176.975 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Xyloglucan 1,6-alpha-xylosidase activity
- Specific Function
- Can catalyze the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose and trehalose.
- Gene Name
- yicI
- Uniprot ID
- P31434
- Uniprot Name
- Alpha-xylosidase
- Molecular Weight
- 88078.905 Da
References
- Kind
- Protein
- Organism
- Rhodococcus erythropolis
- Pharmacological action
- Unknown
- General Function
- Limonene-1,2-epoxide hydrolase activity
- Specific Function
- Catalyzes the conversion of limonene-1,2-epoxide to limonene-1,2-diol. Can use both the (-) and (+) isomers of limonene-1,2-epoxide as substrates and also has some activity with 1-methylcyclohexene...
- Gene Name
- limA
- Uniprot ID
- Q9ZAG3
- Uniprot Name
- Limonene-1,2-epoxide hydrolase
- Molecular Weight
- 16520.47 Da
References
- Kind
- Protein
- Organism
- Cellvibrio japonicus (strain Ueda107)
- Pharmacological action
- Unknown
- General Function
- Mannan endo-1,4-beta-mannosidase activity
- Specific Function
- Catalyzes the endo hydrolysis of beta-1,4-linked mannan and galactomannan, but displays little activity towards other polysaccharides located in the plant cell wall (PubMed:11382747). Preferentiall...
- Gene Name
- manA
- Uniprot ID
- P49424
- Uniprot Name
- Mannan endo-1,4-beta-mannosidase
- Molecular Weight
- 47486.99 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Udp-galactosyltransferase activity
- Specific Function
- The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoprot...
- Gene Name
- B4GALT1
- Uniprot ID
- P15291
- Uniprot Name
- Beta-1,4-galactosyltransferase 1
- Molecular Weight
- 43919.895 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Abelson murine leukemia virus
- Pharmacological action
- Unknown
- General Function
- Non-membrane spanning protein tyrosine kinase activity
- Specific Function
- Not Available
- Gene Name
- ABL
- Uniprot ID
- P00521
- Uniprot Name
- Tyrosine-protein kinase transforming protein Abl
- Molecular Weight
- 81871.395 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Udp-n-acetylglucosamine diphosphorylase activity
- Specific Function
- Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl co...
- Gene Name
- glmU
- Uniprot ID
- P0ACC7
- Uniprot Name
- Bifunctional protein GlmU
- Molecular Weight
- 49189.765 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Protein disulfide oxidoreductase activity
- Specific Function
- Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of...
- Gene Name
- dsbC
- Uniprot ID
- P0AEG6
- Uniprot Name
- Thiol:disulfide interchange protein DsbC
- Molecular Weight
- 25621.495 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Nadp binding
- Specific Function
- Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal i...
- Gene Name
- gapA
- Uniprot ID
- P0A9B2
- Uniprot Name
- Glyceraldehyde-3-phosphate dehydrogenase A
- Molecular Weight
- 35532.24 Da
References
- Kind
- Protein
- Organism
- Pseudomonas putida
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Reduction of (S)-mandelate to benzoylformate.
- Gene Name
- mdlB
- Uniprot ID
- P20932
- Uniprot Name
- (S)-mandelate dehydrogenase
- Molecular Weight
- 43436.53 Da
- Kind
- Protein
- Organism
- Alcaligenes xylosoxydans xylosoxydans
- Pharmacological action
- Unknown
- General Function
- Nitrite reductase (no-forming) activity
- Specific Function
- Not Available
- Gene Name
- nir
- Uniprot ID
- O68601
- Uniprot Name
- Copper-containing nitrite reductase
- Molecular Weight
- 38939.295 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Identical protein binding
- Specific Function
- Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward...
- Gene Name
- hslO
- Uniprot ID
- P0A6Y5
- Uniprot Name
- 33 kDa chaperonin
- Molecular Weight
- 32534.245 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
- Specific Function
- Catalyzes the reversible oxidation-reduction of the R-enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide.
- Gene Name
- msrC
- Uniprot ID
- P76270
- Uniprot Name
- Free methionine-R-sulfoxide reductase
- Molecular Weight
- 18121.45 Da
- Kind
- Protein
- Organism
- Pseudomonas putida (strain KT2440)
- Pharmacological action
- Unknown
- General Function
- Nucleotide binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q88H32
- Uniprot Name
- Ornithine cyclodeaminase
- Molecular Weight
- 38424.515 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Nadph binding
- Specific Function
- The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
- Gene Name
- QDPR
- Uniprot ID
- P09417
- Uniprot Name
- Dihydropteridine reductase
- Molecular Weight
- 25789.295 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Argininosuccinate lyase activity
- Specific Function
- Not Available
- Gene Name
- ASL
- Uniprot ID
- P04424
- Uniprot Name
- Argininosuccinate lyase
- Molecular Weight
- 51657.505 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Ribonuclease inhibitor activity
- Specific Function
- Deacetylates O-acetyl-ADP ribose. Down-regulates ribonuclease 3 (RNase III) activity. Acts by interacting directly with the region of the ribonuclease that is required for dimerization/activation.
- Gene Name
- ymdB
- Uniprot ID
- P0A8D6
- Uniprot Name
- O-acetyl-ADP-ribose deacetylase
- Molecular Weight
- 18880.25 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Microtubule binding
- Specific Function
- Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activ...
- Gene Name
- ARL3
- Uniprot ID
- P36405
- Uniprot Name
- ADP-ribosylation factor-like protein 3
- Molecular Weight
- 20455.335 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Proteus vulgaris
- Pharmacological action
- Unknown
- General Function
- Beta-lactamase activity
- Specific Function
- Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against cephalosporins such as cefuroxime and cefotaxime.
- Gene Name
- blaB
- Uniprot ID
- P52664
- Uniprot Name
- Beta-lactamase
- Molecular Weight
- 32991.385 Da
- Kind
- Protein
- Organism
- Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Involved in the biosynthesis of lipopolysaccharides (LPSs), but is not essential. Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO...
- Gene Name
- Not Available
- Uniprot ID
- P45314
- Uniprot Name
- 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC
- Molecular Weight
- 19432.135 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modification...
- Gene Name
- L3MBTL1
- Uniprot ID
- Q9Y468
- Uniprot Name
- Lethal(3)malignant brain tumor-like protein 1
- Molecular Weight
- 83882.985 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Identical protein binding
- Specific Function
- Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
- Gene Name
- BCHE
- Uniprot ID
- P06276
- Uniprot Name
- Cholinesterase
- Molecular Weight
- 68417.575 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
- Gene Name
- rnz
- Uniprot ID
- P54548
- Uniprot Name
- Ribonuclease Z
- Molecular Weight
- 34022.58 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ubiquitin protein ligase binding
- Specific Function
- Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as wel...
- Gene Name
- PRDX6
- Uniprot ID
- P30041
- Uniprot Name
- Peroxiredoxin-6
- Molecular Weight
- 25034.715 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- mglB
- Uniprot ID
- Q9X9L0
- Uniprot Name
- Hypothetical gliding protein
- Molecular Weight
- 17774.16 Da
- Kind
- Protein
- Organism
- Myxococcus xanthus
- Pharmacological action
- Unknown
- General Function
- Serine-type exopeptidase activity
- Specific Function
- Not Available
- Gene Name
- pep
- Uniprot ID
- Q9X5N2
- Uniprot Name
- Prolyl endopeptidase Pep
- Molecular Weight
- 76847.12 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Lipid transporter activity
- Specific Function
- In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for ...
- Gene Name
- SFTPA1
- Uniprot ID
- Q8IWL2
- Uniprot Name
- Pulmonary surfactant-associated protein A1
- Molecular Weight
- 26242.275 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Lactobacillus plantarum
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- P60355
- Uniprot Name
- Manganese catalase
- Molecular Weight
- 29743.225 Da
- Kind
- Protein
- Organism
- Thermus thermophilus
- Pharmacological action
- Unknown
- General Function
- Chorismate mutase activity
- Specific Function
- Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
- Gene Name
- aroH
- Uniprot ID
- Q84FH6
- Uniprot Name
- Chorismate mutase AroH
- Molecular Weight
- 13649.555 Da
- Kind
- Protein
- Organism
- Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- Specific Function
- Catalyze oxidative C-C coupling reaction to polymerize flaviolin and form highly conjugated pigments which protect the soil bacterium from deleterious effects of UV irradiation (three isomers of bi...
- Gene Name
- cyp158a2
- Uniprot ID
- Q9FCA6
- Uniprot Name
- Biflaviolin synthase CYP158A2
- Molecular Weight
- 44354.085 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Hydrolase activity
- Specific Function
- Not Available
- Gene Name
- IRGC
- Uniprot ID
- Q6NXR0
- Uniprot Name
- Interferon-inducible GTPase 5
- Molecular Weight
- 50287.62 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52