NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

BE0000525ProteinHumansNDUFA13

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). It is acted on by 2 drugs in DrugBank.

Gene name
NDUFA13
UniProtKB entry
Q9P0J0Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
144 residues · 16,698 Da
Also known as
Cell death regulatory protein GRIM-19 · CI-B16.6 · Complex I-B16.6 · Gene associated with retinoic and IFN-induced mortality 19 protein · Gene associated with retinoic and interferon-induced mortality 19 protein

Resolves to

Protein
UniProtQ9P0J0UniProt nameNDUAD_HUMAN
Gene
HGNCHGNC:17194NCBI Gene51079GenBank11055599GeneCardsNDUFA13
Pharmacology
KEGGhsa:51079
Structure
PDB5XTBPDB5XTCPDB5XTD
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13, how selective are they, and which programs against it are still in active trials?

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