Nicotinate-nucleotide pyrophosphorylase [carboxylating]

BE0000526ProteinHumansQPRT

Involved in the catabolism of quinolinic acid (QA). It is acted on by 1 drug in DrugBank.

Gene name
QPRT
UniProtKB entry
Q15274Swiss-Prot
Residues / weight
297 residues · 30,845 Da
Also known as
2.4.2.19 · QAPRTase · QPRTase · Quinolinate phosphoribosyltransferase [decarboxylating]

Resolves to

Protein
UniProtQ15274UniProt nameNADC_HUMAN
Gene
HGNCHGNC:9755NCBI Gene23475GenBank1060907GeneCardsQPRT
Pharmacology
KEGGhsa:23475
Structure
PDB2JBMPDB4KWVPDB4KWW
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nicotinate-nucleotide pyrophosphorylase [carboxylating], how selective are they, and which programs against it are still in active trials?

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