Aspartyl/asparaginyl beta-hydroxylase

BE0000528ProteinHumansASPH

Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins. It is acted on by 2 drugs in DrugBank.

Gene name
ASPH
UniProtKB entry
Q12797Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
758 residues · 85,862 Da
Also known as
1.14.11.16 · ASP beta-hydroxylase · Aspartate beta-hydroxylase · BAH · Peptide-aspartate beta-dioxygenase

Resolves to

Protein
UniProtQ12797UniProt nameASPH_HUMAN
Gene
HGNCHGNC:757NCBI Gene444GenBank458032GeneCardsASPH
Pharmacology
KEGGhsa:444
Structure
PDB5APAPDB5JQYPDB5JTC
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
20+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Aspartyl/asparaginyl beta-hydroxylase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In