Methionine--tRNA ligase, cytoplasmic

BE0000543ProteinHumansMARS1

Catalyzes the specific attachment of L-methionine to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of... It is acted on by 2 drugs in DrugBank.

Gene name
MARS1
UniProtKB entry
P56192Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
900 residues · 101,115 Da
Also known as
6.1.1.10 · MARS · Methionyl-tRNA synthetase · MetRS

Resolves to

Protein
UniProtP56192UniProt nameSYMC_HUMAN
Gene
HGNCHGNC:6898NCBI Gene4141GenBank1702932GeneCardsMARS1
Pharmacology
KEGGhsa:4141
Structure
PDB2DJVPDB4BL7PDB4BVX
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Methionine--tRNA ligase, cytoplasmic, how selective are they, and which programs against it are still in active trials?

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