Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

BE0000559ProteinHumansIDH3B

Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. It is acted on by 3 drugs in DrugBank.

Gene name
IDH3B
UniProtKB entry
O43837Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
385 residues · 42,183 Da
Also known as
Isocitric dehydrogenase subunit beta · NAD(+)-specific ICDH subunit beta

Resolves to

Protein
UniProtO43837UniProt nameIDH3B_HUMAN
Gene
HGNCHGNC:5385NCBI Gene3420GenBank2737886GeneCardsIDH3B
Pharmacology
KEGGhsa:3420
Structure
PDB6KDEPDB6KDFPDB6KDY
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
2GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
14+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In