Bifunctional dihydrofolate reductase-thymidylate synthase

BE0000563ProteinPlasmodium falciparum (isolate K1 / Thailand)

Bifunctional enzyme. It is acted on by 4 drugs in DrugBank.

UniProtKB entry
P13922Swiss-Prot
Residues / weight
608 residues · 71,817 Da
Also known as
DHFR-TS

Resolves to

Protein
UniProtP13922UniProt nameDRTS_PLAFK
Gene
GenBank160260
Structure
PDB1J3IPDB1J3JPDB1J3K
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bifunctional dihydrofolate reductase-thymidylate synthase, how selective are they, and which programs against it are still in active trials?

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