(3R)-3-hydroxyacyl-CoA dehydrogenase

BE0000578ProteinHumansHSD17B8

Required for the solubility and assembly of the heterotetramer 3-ketoacyl-acyl carrier protein (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). It is acted on by 2 drugs in DrugBank.

Gene name
HSD17B8
UniProtKB entry
Q92506Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
261 residues · 26,974 Da
Also known as
1.1.1.n12 · 17-beta-HSD 8 · 17-beta-hydroxysteroid dehydrogenase 8 · 3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit · 3-oxoacyl-[acyl-carrier-protein] reductase

Resolves to

Protein
UniProtQ92506UniProt nameDHB8_HUMAN
Gene
HGNCHGNC:3554NCBI Gene7923GenBank30583317GeneCardsHSD17B8
Pharmacology
KEGGhsa:7923
Structure
PDB2PD6PDB4CQLPDB4CQM
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on (3R)-3-hydroxyacyl-CoA dehydrogenase, how selective are they, and which programs against it are still in active trials?

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