Heme oxygenase 2

BE0000587ProteinHumansHMOX2

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. It is acted on by 2 drugs in DrugBank.

Gene name
HMOX2
UniProtKB entry
P30519Swiss-Prot
Cellular location
Microsome membrane
Residues / weight
316 residues · 36,033 Da
Also known as
1.14.14.18 · HO-2 · HO2

Resolves to

Protein
UniProtP30519UniProt nameHMOX2_HUMAN
Gene
HGNCHGNC:5014NCBI Gene3163GenBank443771GeneCardsHMOX2
Pharmacology
KEGGhsa:3163
Structure
PDB2Q32PDB2QPPPDB2RGZ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Heme oxygenase 2, how selective are they, and which programs against it are still in active trials?

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