ADP/ATP translocase 1

BE0000599ProteinHumansSLC25A4

ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:21586654, PubMed:27693233, PubMed:23173940, PubMed:30046662). It is acted on by 7 drugs in DrugBank.

Gene name
SLC25A4
UniProtKB entry
P12235Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
298 residues · 33,064 Da
Also known as
AAC1 · Adenine nucleotide translocator 1 · ADP,ATP carrier protein 1 · ADP,ATP carrier protein, heart/skeletal muscle isoform T1 · ANT 1

Resolves to

Protein
UniProtP12235UniProt nameADT1_HUMAN
Gene
HGNCHGNC:10990NCBI Gene291GenBank339920GeneCardsSLC25A4
Pharmacology
KEGGhsa:291
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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30+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ADP/ATP translocase 1, how selective are they, and which programs against it are still in active trials?

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