Solute carrier family 12 member 4

BE0000601ProteinHumansSLC12A4

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:35759661). It is acted on by 2 drugs in DrugBank.

Gene name
SLC12A4
UniProtKB entry
Q9UP95Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,085 residues · 120,649 Da
Also known as
Electroneutral potassium-chloride cotransporter 1 · Erythroid K-Cl cotransporter 1 · hKCC1 · KCC1

Resolves to

Protein
UniProtQ9UP95UniProt nameS12A4_HUMAN
Gene
HGNCHGNC:10913NCBI Gene6560GenBank1399212GeneCardsSLC12A4
Pharmacology
KEGGhsa:6560
Structure
PDB6KKRPDB6KKTPDB6KKU
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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21+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Solute carrier family 12 member 4, how selective are they, and which programs against it are still in active trials?

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