Phosphoserine aminotransferase

BE0000603ProteinHumansPSAT1

Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine (PubMed:36851825, PubMed:37627284). It is acted on by 2 drugs in DrugBank.

Gene name
PSAT1
UniProtKB entry
Q9Y617Swiss-Prot
Residues / weight
370 residues · 40,422 Da
Also known as
2.6.1.52 · Phosphohydroxythreonine aminotransferase · PSA · PSAT

Resolves to

Protein
UniProtQ9Y617UniProt nameSERC_HUMAN
Gene
HGNCHGNC:19129NCBI Gene29968GenBank5326802GeneCardsPSAT1
Pharmacology
KEGGhsa:29968
Structure
PDB3E77PDB8A5VPDB8A5W
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphoserine aminotransferase, how selective are they, and which programs against it are still in active trials?

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