Isobutyryl-CoA dehydrogenase, mitochondrial

BE0000605ProteinHumansACAD8

Isobutyryl-CoA dehydrogenase which catalyzes the conversion of 2-methylpropanoyl-CoA to (2E)-2-methylpropenoyl-CoA in the valine catabolic pathway (PubMed:11013134, PubMed:12359132, PubMed:16857760). It is acted on by 2 drugs in DrugBank.

Gene name
ACAD8
UniProtKB entry
Q9UKU7Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
415 residues · 45,069 Da
Also known as
1.3.8.5 · ACAD-8 · Activator-recruited cofactor 42 kDa component · Acyl-CoA dehydrogenase family member 8 · ARC42

Resolves to

Protein
UniProtQ9UKU7UniProt nameACAD8_HUMAN
Gene
HGNCHGNC:87NCBI Gene27034GenBank6465955GeneCardsACAD8
Pharmacology
KEGGhsa:27034
Structure
PDB1RX0
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isobutyryl-CoA dehydrogenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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