Na(+)/dicarboxylate cotransporter 3

BE0000611ProteinHumansSLC13A3

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:10794676, PubMed:10992006, PubMed:15561973, PubMed:17356845,... It is acted on by 2 drugs in DrugBank.

Gene name
SLC13A3
UniProtKB entry
Q8WWT9Swiss-Prot
Cellular location
Cell membrane
Residues / weight
602 residues · 66,840 Da
Also known as
hNaDC3 · Na(+)-coupled carboxylate transporter 3 · NaC3 · NaDC-3 · NADC3

Resolves to

Protein
UniProtQ8WWT9UniProt nameS13A3_HUMAN
Gene
HGNCHGNC:14430NCBI Gene64849GenBank8132324GeneCardsSLC13A3
Pharmacology
KEGGhsa:64849
Structure
PDB8UVCPDB8UVDPDB8UVE
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Na(+)/dicarboxylate cotransporter 3, how selective are they, and which programs against it are still in active trials?

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