Choline-phosphate cytidylyltransferase A

BE0000615ProteinHumansPCYT1A

Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. It is acted on by 4 drugs in DrugBank.

Gene name
PCYT1A
UniProtKB entry
P49585Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
367 residues · 41,731 Da
Also known as
2.7.7.15 · CCT A · CCT-alpha · CT A · CTP:phosphocholine cytidylyltransferase A

Resolves to

Protein
UniProtP49585UniProt namePCY1A_HUMAN
Gene
HGNCHGNC:8754NCBI Gene5130GenBank575486GeneCardsPCYT1A
Pharmacology
KEGGhsa:5130
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Choline-phosphate cytidylyltransferase A, how selective are they, and which programs against it are still in active trials?

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