UMP-CMP kinase
Details
- Name
- UMP-CMP kinase
- Kind
- protein
- Synonyms
- 2.7.4.14
- CK
- CMK
- CMPK
- dCMP kinase
- Deoxycytidylate kinase
- Nucleoside-diphosphate kinase
- UCK
- UMK
- UMP/CMP kinase
- UMP/CMPK
- UMPK
- Uridine monophosphate/cytidine monophosphate kinase
- Gene Name
- CMPK1
- UniProtKB Entry
- P30085Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0001270|UMP-CMP kinase MKPLVVFVLGGPGAGKGTQCARIVEKYGYTHLSAGELLRDERKNPDSQYGELIEKYIKEG KIVPVEITISLLKREMDQTMAANAQKNKFLIDGFPRNQDNLQGWNKTMDGKADVSFVLFF DCNNEICIERCLERGKSSGRSDDNRESLEKRIQTYLQSTKPIIDLYEEMGKVKKIDASKS VDEVFDEVVQIFDKEG
- Number of residues
- 196
- Molecular Weight
- 22222.175
- Theoretical pI
- 5.2
- GO Classification
- Functions(d)CMP kinase activity / CMP kinase activity / dCMP kinase activity / nucleoside monophosphate kinase activity / UMP kinase activityProcessesCDP biosynthetic process / UDP biosynthetic processComponentsnucleolus / nucleoplasm
- General Function
- Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity
- Specific Function
- (d)CMP kinase activity
- Pfam Domain Function
- ADK (PF00406)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0010444|UMP-CMP kinase (CMPK1) ATGCTGAGCCGCTGCCGCAGCGGGCTGCTCCACGTCCTGGGCCTTAGCTTCCTGCTGCAG ACCCGCCGGCCGATTCTCCTCTGCTCTCCACGTCTCATGAAGCCGCTGGTCGTGTTCGTC CTCGGCGGCCCCGGCGCCGGCAAGGGGACCCAGTGCGCCCGCATCGTCGAGGAAATGGAT CAGACAATGGCTGCCAATGCTCAGAAGAATAAATTCTTGATTGATGGGTTTCCAAGAAAT CAAGACAACCTTCAAGGATGGAACAAGACCATGGATGGGAAGGCAGATGTATCTTTCGTT CTCTTTTTTGACTGTAATAATGAGATTTGTATTGAACGATGTCTTGAGAGGGGAAAGAGT AGTGGTAGGAGTGATGACAACAGAGAGAGCTTGGAAAAGAGAATTCAGACCTACCTTCAG TCAACAAAGCCAATTATTGACTTATATGAAGAAATGGGGAAAGTCAAGAAAATAGATGCT TCTAAATCTGTTGATGAAGTTTTTGATGAAGTTGTGCAGATTTTTGACAAGGAAGGCTAA
- Chromosome Location
- 1
- Locus
- 1p33
- External Identifiers
Resource Link UniProtKB ID P30085 UniProtKB Entry Name KCY_HUMAN GenBank Protein ID 6578133 GenBank Gene ID AF070416 GeneCard ID CMPK1 GenAtlas ID CMPK HGNC ID HGNC:18170 PDB ID(s) 1TEV, 7E9V KEGG ID hsa:51727 NCBI Gene ID 51727 - General References
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- Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC: Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. [Article]
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- Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013 May;45(5):925-31. doi: 10.1016/j.biocel.2013.02.004. Epub 2013 Feb 14. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Gemcitabine approved unknown target inhibitor Details Cytidine-5'-Monophosphate experimental unknown target Details Uridine-5'-Diphosphate experimental unknown target Details P1-(adenosine-5'-P5-(uridine-5')pentaphosphate experimental unknown target Details Tetrafluoroaluminate Ion experimental unknown target Details Lamivudine approved, investigational unknown enzyme substrate Details Sofosbuvir approved unknown enzyme substrate Details Decitabine approved, investigational yes enzyme substrate Details Gemcitabine approved no enzyme substrate Details