Tetrafluoroaluminate Ion
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Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- Tetrafluoroaluminate Ion
- DrugBank Accession Number
- DB04444
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 102.9752
Monoisotopic: 102.975151261 - Chemical Formula
- AlF4
- Synonyms
- Tetrafluoroaluminate anion
- tetrafluoroaluminate(1−)
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UMyosin-14 Not Available Humans UProtein RecA Not Available Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) UAcetylglutamate kinase Not Available Escherichia coli (strain K12) UGuanine nucleotide-binding protein G(i) subunit alpha-1 Not Available Humans USarcoplasmic/endoplasmic reticulum calcium ATPase 1 Not Available Humans UGuanine nucleotide-binding protein G(t) subunit alpha-1 Not Available Humans UUMP-CMP kinase Not Available Humans UMyosin-11 Not Available Humans URibokinase Not Available Escherichia coli (strain K12) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal salts
- Sub Class
- Post-transition metal fluorides
- Direct Parent
- Post-transition metal fluorides
- Alternative Parents
- Inorganic salts
- Substituents
- Inorganic salt / Post-transition metal fluoride
- Molecular Framework
- Not Available
- External Descriptors
- aluminium coordination entity, perfluorometallate anion (CHEBI:30111)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- 21340-02-3
- InChI Key
- UYOMQIYKOOHAMK-UHFFFAOYSA-J
- InChI
- InChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
- IUPAC Name
- tetrafluoroalumanuide
- SMILES
- F[Al](F)(F)[F-]
References
- General References
- Not Available
- External Links
- PDB Entries
- 1agr / 1br1 / 1br2 / 1fqj / 1fqk / 1g18 / 1gfi / 1h8e / 1l7n / 1m34 … show 220 more
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 2.82 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 6.01 m3·mol-1 Chemaxon Polarizability 4.37 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9363 Blood Brain Barrier + 0.987 Caco-2 permeable + 0.5263 P-glycoprotein substrate Non-substrate 0.8968 P-glycoprotein inhibitor I Non-inhibitor 0.9653 P-glycoprotein inhibitor II Non-inhibitor 0.976 Renal organic cation transporter Non-inhibitor 0.9332 CYP450 2C9 substrate Non-substrate 0.8373 CYP450 2D6 substrate Non-substrate 0.6634 CYP450 3A4 substrate Non-substrate 0.7086 CYP450 1A2 substrate Non-inhibitor 0.6831 CYP450 2C9 inhibitor Non-inhibitor 0.7845 CYP450 2D6 inhibitor Non-inhibitor 0.9077 CYP450 2C19 inhibitor Non-inhibitor 0.7717 CYP450 3A4 inhibitor Non-inhibitor 0.9138 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9373 Ames test Non AMES toxic 0.9235 Carcinogenicity Carcinogens 0.664 Biodegradation Not ready biodegradable 0.8821 Rat acute toxicity 2.7180 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9567 hERG inhibition (predictor II) Non-inhibitor 0.8895
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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1. DetailsMyosin-14
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping
- Specific Function
- actin filament binding
- Gene Name
- MYH14
- Uniprot ID
- Q7Z406
- Uniprot Name
- Myosin-14
- Molecular Weight
- 227868.56 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
2. DetailsProtein RecA
- Kind
- Protein
- Organism
- Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
- Pharmacological action
- Unknown
- General Function
- Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
- Specific Function
- ATP binding
- Gene Name
- recA
- Uniprot ID
- P62219
- Uniprot Name
- Protein RecA
- Molecular Weight
- 37464.435 Da
References
3. DetailsAcetylglutamate kinase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
- Specific Function
- acetylglutamate kinase activity
- Gene Name
- argB
- Uniprot ID
- P0A6C8
- Uniprot Name
- Acetylglutamate kinase
- Molecular Weight
- 27159.285 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:18434541, PubMed:8774883, PubMed:34239069, PubMed:33762731, PubMed:35610220, PubMed:37963465, PubMed:37935377, PubMed:37935376, PubMed:38552625). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:18434541, PubMed:8774883). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:18434541, PubMed:8774883). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:18434541, PubMed:8774883). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:18434541, PubMed:8774883). Signaling is mediated via effector proteins, such as adenylate cyclase: inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (PubMed:8119955). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364)
- Specific Function
- D2 dopamine receptor binding
- Gene Name
- GNAI1
- Uniprot ID
- P63096
- Uniprot Name
- Guanine nucleotide-binding protein G(i) subunit alpha-1
- Molecular Weight
- 40360.685 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (By similarity). Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:10914677)
- Specific Function
- ATP binding
- Gene Name
- ATP2A1
- Uniprot ID
- O14983
- Uniprot Name
- Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
- Molecular Weight
- 110251.36 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Functions as a signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (PubMed:22190596). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (By similarity)
- Specific Function
- acyl binding
- Gene Name
- GNAT1
- Uniprot ID
- P11488
- Uniprot Name
- Guanine nucleotide-binding protein G(t) subunit alpha-1
- Molecular Weight
- 40040.415 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
7. DetailsUMP-CMP kinase
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity
- Specific Function
- (d)CMP kinase activity
- Gene Name
- CMPK1
- Uniprot ID
- P30085
- Uniprot Name
- UMP-CMP kinase
- Molecular Weight
- 22222.175 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
8. DetailsMyosin-11
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Muscle contraction
- Specific Function
- actin filament binding
- Gene Name
- MYH11
- Uniprot ID
- P35749
- Uniprot Name
- Myosin-11
- Molecular Weight
- 227337.455 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
9. DetailsRibokinase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
- Specific Function
- ATP binding
- Gene Name
- rbsK
- Uniprot ID
- P0A9J6
- Uniprot Name
- Ribokinase
- Molecular Weight
- 32290.19 Da
References
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:52