Alpha-tocopherol transfer protein

BE0000643ProteinHumansTTPA

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). It is acted on by 7 drugs in DrugBank.

Gene name
TTPA
UniProtKB entry
P49638Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
278 residues · 31,749 Da
Also known as
Alpha-TTP · TPP1

Resolves to

Protein
UniProtP49638UniProt nameTTPA_HUMAN
Gene
HGNCHGNC:12404NCBI Gene7274GenBank699601GeneCardsTTPA
Pharmacology
KEGGhsa:7274
Structure
PDB1OIPPDB1OIZPDB1R5L
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-tocopherol transfer protein, how selective are they, and which programs against it are still in active trials?

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