Troponin I, cardiac muscle

BE0000656ProteinHumansTNNI3

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. It is acted on by 2 drugs in DrugBank.

Gene name
TNNI3
UniProtKB entry
P19429Swiss-Prot
Residues / weight
210 residues · 24,007 Da
Also known as
Cardiac troponin I · TNNC1

Resolves to

Protein
UniProtP19429UniProt nameTNNI3_HUMAN
Gene
HGNCHGNC:11947NCBI Gene7137GenBank37428GeneCardsTNNI3
Pharmacology
KEGGhsa:7137
Structure
PDB1J1DPDB1J1EPDB1LXF
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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14Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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25+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Troponin I, cardiac muscle, and which indications are they being tested in?

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