Argininosuccinate synthase

BE0000671ProteinHumansASS1

One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. It is acted on by 4 drugs in DrugBank.

Gene name
ASS1
UniProtKB entry
P00966Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
412 residues · 46,530 Da
Also known as
6.3.4.5 · ASS · Citrulline--aspartate ligase

Resolves to

Protein
UniProtP00966UniProt nameASSY_HUMAN
Gene
HGNCHGNC:758NCBI Gene445GenBank28872GeneCardsASS1
Pharmacology
KEGGhsa:445
Structure
PDB2NZ2
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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37+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Argininosuccinate synthase, how selective are they, and which programs against it are still in active trials?

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