Acid-sensing ion channel 2

BE0000678ProteinHumansASIC2

Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system (PubMed:10842183, PubMed:23034652, PubMed:8626462, PubMed:8631835). It is acted on by 1 drug in DrugBank.

Gene name
ASIC2
UniProtKB entry
Q16515Swiss-Prot
Cellular location
Cell membrane
Residues / weight
512 residues · 57,709 Da
Also known as
ACCN · ACCN1 · Amiloride-sensitive cation channel 1, neuronal · Amiloride-sensitive cation channel neuronal 1 · ASIC2

Resolves to

Protein
UniProtQ16515UniProt nameASIC2_HUMAN
Gene
HGNCHGNC:99NCBI Gene40GenBank1256017GeneCardsASIC2
Pharmacology
IUPHAR/GtoPdb685KEGGhsa:40
Structure
PDB6L6P
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Acid-sensing ion channel 2, how selective are they, and which programs against it are still in active trials?

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