Amiloride is a pyrizine compound used to treat hypertension and congestive heart failure. A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
- Mechanism
- Curator reviewed
Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium. Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.
- Primary indication
- For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.Curator reviewed · 17 structured indications
- Formula / weight
- C6H8ClN7O · 229.627 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1986
- Also known as
- Amipramidin · Amipramidine · Amyloride
- Code names
- MK 870
- Brand names
Resolves to
XSDQTOBWRPYKKA-UHFFFAOYSA-NSMILESNC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1NWhat you can answer from here — as of September 30, 2026
Which drugs share a target with Amiloride, and which of those have an active Phase 3 trial?
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