RNA-directed RNA polymerase L

BE0000681ProteinHPIV-2L

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. It is acted on by 2 drugs in DrugBank.

Gene name
L
UniProtKB entry
P26676Swiss-Prot
Cellular location
Virion
Residues / weight
2,262 residues · 256,380 Da
Also known as
Large structural protein · Protein L · Replicase · Transcriptase

Resolves to

Protein
UniProtP26676UniProt nameL_PI2HT
Gene
NCBI Gene935189GenBank61991
Pharmacology
KEGGvg:935189
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on RNA-directed RNA polymerase L, how selective are they, and which programs against it are still in active trials?

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