Free fatty acid receptor 1

BE0000688ProteinHumansFFAR1

G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. It is acted on by 9 drugs in DrugBank.

Gene name
FFAR1
UniProtKB entry
O14842Swiss-Prot
Cellular location
Cell membrane
Residues / weight
300 residues · 31,457 Da
Also known as
G protein-coupled receptor 40 · GPR40

Resolves to

Protein
UniProtO14842UniProt nameFFAR1_HUMAN
Gene
HGNCHGNC:4498NCBI Gene2864GenBank2612946GeneCardsFFAR1
Pharmacology
IUPHAR/GtoPdb225KEGGhsa:2864
Structure
PDB4PHUPDB5KW2PDB5TZR
Drugs

What you can answer from here — as of September 07, 2019

9DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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33+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Free fatty acid receptor 1, how selective are they, and which programs against it are still in active trials?

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